After chemotherapy ends
LYNPARZA helps keep your ovarian cancer from growing or returning

After chemotherapy ends
LYNPARZA helps keep your ovarian cancer from growing or returning

LYNPARZA can help preserve the progress you’ve seen from chemotherapy

The goal of treating advanced cancer is usually to shrink the cancer and control its growth for as long as possible. At some point, you may receive chemotherapy. This type of treatment can be used to reach almost all areas of the body and may be given intravenously or orally. Your cancer may respond to chemotherapy by shrinking or disappearing.

Unfortunately, more than 70% of women will see their ovarian cancer return within 3 years after chemotherapy. That’s why your health care provider may choose between 2 approaches after treatment has ended: a watch-and-wait approach or an active maintenance approach, like LYNPARZA.

WATCH-AND-WAIT APPROACH

This approach means that your health care provider will closely monitor you with blood tests and possibly scans to see if the cancer returns or grows. Throughout the duration of this approach, you will not be taking medication to keep your cancer from coming back.

ACTIVE MAINTENANCE APPROACH

Another option your health care provider may choose is an active approach called maintenance treatment. Your health care provider will monitor you while taking this prescription medication to see if the cancer returns or grows. LYNPARZA is a type of oral maintenance treatment known as a targeted therapy, which is different from the chemotherapy you may have received in the past.

A maintenance treatment can potentially work in 2 ways:

  • 1. To maintain the progress you’ve seen with your treatment.
  • 2. To keep cancer from coming back for a longer period of time.

Both may help extend the time you spend progression free.

Unlock the potential for more time progression free. Ask your health care provider about LYNPARZA: a type of active maintenance treatment to help keep your cancer from growing or returning.

Your health care provider will help guide you through the process of treatment to see which medicine may be best for you.

Treatment

You could be eligible for an active approach. Why wait to talk to your doctor about LYNPARZA?

LYNPARZA is an alternative to the watch-and-wait approach

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Facts about LYNPARZA

LYNPARZA is an active maintenance treatment. Let’s take a look at some quick facts about LYNPARZA:

A PROVEN TREATMENT

Two clinical trials proved that LYNPARZA helps keep cancer from coming back for a longer period of time in women with certain types of advanced ovarian cancer. See the data.

NOT CHEMOTHERAPY

LYNPARZA is not chemotherapy; it’s a targeted therapy called a PARP inhibitor.

BRCA MUTATIONS

LYNPARZA is a maintenance treatment for women regardless of whether or not they have a BRCA mutation.

TAKEN ORALLY

LYNPARZA is taken orally with 2 tablets (150 mg each) taken 2 times a day (300 mg per dose), totaling 4 tablets each day.

PARP=poly (ADP-ribose) polymerase.

To better understand when you can use LYNPARZA to help maintain your response, take a look at this timeline example.

Timeline of when you can use LYNPARZA to maintain your response

diagnosed
 

Ovarian cancer is diagnosed.

 

Treated with chemotherapy.

cancer
 

Cancer returns or grows.

 

Treated with chemotherapy.

tablet
 

Cancer is responding to chemotherapy.

 

May be eligible for treatment with LYNPARZA.

Treatment

After chemotherapy, talk to your doctor about an active maintenance approach with LYNPARZA.

Important Safety Information

WHAT IS LYNPARZA?

LYNPARZA is a prescription medicine used to treat adults:

  • who have ovarian cancer, fallopian tube cancer, or primary peritoneal cancer, when the cancer has come back. LYNPARZA is used after the cancer has responded to treatment with platinum-based chemotherapy
    or
  • who have advanced ovarian cancer with a certain type of abnormal inherited BRCA gene, and have received treatment with 3 or more prior types of chemotherapy medicines. Your health care provider will perform a test to make sure that LYNPARZA is right for you

It is not known if LYNPARZA is safe and effective in children.

IMPORTANT SAFETY INFORMATION

LYNPARZA may cause serious side effects, including:

Bone marrow problems called Myelodysplastic Syndrome (MDS) or Acute Myeloid Leukemia (AML). Some people who have ovarian cancer or breast cancer and who have received previous treatment with chemotherapy, radiotherapy, or certain other medicines for their cancer have developed MDS or AML during treatment with LYNPARZA. MDS or AML may lead to death. If you develop MDS or AML, your health care provider will stop treatment with LYNPARZA.

Symptoms of low blood cell counts are common during treatment with LYNPARZA, but can be a sign of serious bone marrow problems, including MDS or AML. Symptoms may include weakness, weight loss, fever, frequent infections, blood in urine or stool, shortness of breath, feeling very tired, bruising or bleeding more easily.

Your health care provider will do blood tests to check your blood cell counts:

  • before treatment with LYNPARZA
  • every month during treatment with LYNPARZA
  • weekly if you have low blood cell counts that last a long time. Your health care provider may stop treatment with LYNPARZA until your blood cell counts improve.

Lung problems (pneumonitis). Tell your health care provider if you have any new or worsening symptoms of lung problems, including shortness of breath, fever, cough, or wheezing. Your health care provider may do a chest x-ray if you have any of these symptoms. Your health care provider may temporarily or completely stop treatment if you develop pneumonitis. Pneumonitis may lead to death.

Before taking LYNPARZA, tell your health care provider about all of your medical conditions, including if you:

  • have lung or breathing problems
  • have kidney problems
  • are pregnant, become pregnant, or plan to become pregnant. LYNPARZA can harm your unborn baby and may cause loss of pregnancy (miscarriage).
    • If you are able to become pregnant, your health care provider may do a pregnancy test before you start treatment with LYNPARZA
    • Females who are able to become pregnant should use effective birth control (contraception) during treatment with LYNPARZA and for 6 months after the last dose of LYNPARZA. Talk to your health care provider about birth control methods that may be right for you
  • are breastfeeding or plan to breastfeed. It is not known if LYNPARZA passes into your breast milk. Do not breastfeed during treatment with LYNPARZA and for 1 month after receiving the last dose of LYNPARZA. Talk to your health care provider about the best way to feed your baby during this time.

Tell your health care provider right away if you become pregnant.

Tell your health care provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Taking LYNPARZA and certain other medicines may affect how LYNPARZA works and may cause side effects.

How should I take LYNPARZA?

  • Take LYNPARZA tablets exactly as your health care provider tells you
  • Your health care provider may temporarily stop treatment with LYNPARZA or change your dose of LYNPARZA if you experience side effects
  • Do not take more than 4 LYNPARZA tablets in 1 day. If you have any questions about LYNPARZA, talk to your health care provider or pharmacist
  • Take LYNPARZA by mouth 2 times a day
  • Each dose should be taken about 12 hours apart
  • Swallow LYNPARZA tablets whole. Do not chew, crush, dissolve, or divide the tablets
  • Take LYNPARZA with or without food
  • If you miss a dose of LYNPARZA, take your next dose at your usual scheduled time
  • Do not take an extra dose to make up for a missed dose
  • If you take too much LYNPARZA, call your health care provider or go to the nearest hospital emergency room right away

What should I avoid while taking LYNPARZA?

Avoid grapefruit, grapefruit juice, Seville oranges, and Seville orange juice during treatment with LYNPARZA since they may increase the level of LYNPARZA in your blood.

LYNPARZA may cause serious side effects (see above). The most common side effects of LYNPARZA are:

  • nausea or vomiting. Tell your health care provider if you get nausea or vomiting. Your health care provider may prescribe medicines to treat these symptoms
  • low number of red or white blood cells
  • tiredness or weakness
  • sore throat or runny nose
  • diarrhea
  • joint, muscle, and back pain
  • headache
  • constipation
  • changes in the way food tastes
  • loss of appetite
  • mouth sores
  • respiratory infections
  • changes in kidney function blood test
  • low number of platelets
  • indigestion or heartburn

These are not all the possible side effects of LYNPARZA. Call your health care provider for medical advice about side effects.

You may report side effects related to AstraZeneca products by clicking here.

Please see complete Prescribing Information, including Patient Information (Medication Guides).