Your BRCA mutation could mean that you are eligible for LYNPARZA

Getting tested for a BRCA mutation can provide you with additional treatment options and inform your family’s future.

BRCA-mutated ovarian cancer

BRCA1 and BRCA2 are human genes that, when they work properly, prevent tumors from forming by producing proteins that help maintain DNA function. When a BRCA1 or BRCA2 gene has a mutation, it does not work properly and, thus, DNA damage may not be repaired. That makes cells more likely to become cancerous. Although BRCA1 and BRCA2 gene mutations are most commonly associated with BReast CAncer (for which they were named), they are found in about 15% of women with ovarian cancer.

Nearly half of all women with ovarian cancer who also have a BRCA mutation have no relevant family history of breast or ovarian cancer. Moreover, a person’s age or ethnicity cannot be used to reliably predict who may carry a BRCA mutation.

Talk to your physician about being tested for a BRCA1/BRCA2 mutation.

How to learn your BRCA mutation status

For women with ovarian cancer, BRCA testing is covered by most insurance providers, including Medicare. Talk to your healthcare provider or insurance plan administrator to learn about your coverage.

If you test positive for a BRCA1/BRCA2 mutation

Learning that you have a BRCA1/BRCA2 mutation can be an emotional experience because of its hereditary implications. It can also provide information to help you and your healthcare provider make decisions about treatment options.

If you do have BRCA-mutated ovarian cancer, ask your physician about LYNPARZA, a medicine approved for women with BRCA-mutated advanced ovarian cancer who have received 3 or more rounds of chemotherapy.

Platinum-based chemotherapy is a type of chemotherapy used to treat cancer. However, cancer can stop being sensitive to platinum-based chemotherapy and become resistant to platinum-based chemotherapy. Talk to your doctor about your condition to determine if LYNPARZA is a treatment option for you.


For over 2 years, doctors have been using LYNPARZA to treat patients with BRCA-mutated advanced ovarian cancer who have received 3 or more prior lines of chemotherapy

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Improve your understanding with definitions of important terms

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LYNPARZA is a prescription medicine used to treat women with advanced ovarian cancer who have received previous treatment with 3 or more prior chemotherapy medicines or a combination of chemotherapy medicines for their cancer, and have a certain type of abnormal inherited BRCA gene.

Your healthcare provider will perform a test to make sure that LYNPARZA is right for you.

Please see Important Safety Information below.


There are no contraindications (a condition in which the treatment should not be used) for LYNPARZA.

LYNPARZA may cause serious side effects that can lead to death including bone marrow problems and lung problems. Some people who have..Read More ovarian cancer or who have received previous treatment with chemotherapy, radiotherapy or certain other medicines for their cancer have developed bone marrow problems called Myelodysplastic syndrome (MDS) or Acute Myeloid Leukemia (AML) during treatment with LYNPARZA. If you develop MDS or AML, your healthcare provider will stop treatment with LYNPARZA.

Symptoms of low blood cell counts are common during treatment with LYNPARZA, but can be a sign of serious bone marrow problems, including MDS or AML. Symptoms to discuss with your healthcare provider include weakness, weight loss, fever, frequent infections, blood in your urine/stool, shortness of breath, feeling very tired, and bruising or bleeding more easily.

You will undergo blood tests before, and every month during, treatment with LYNPARZA to monitor your blood cell counts. Weekly blood tests will be performed if you have low blood cell counts that last a long time. Your healthcare provider may stop treatment with LYNPARZA until your blood cell counts improve.

Tell your healthcare provider if you have any new or worsening symptoms of lung problems, including shortness of breath, fever, cough, or wheezing. Your healthcare provider may do a chest x-ray if you have any of these symptoms. Your healthcare provider may temporarily or completely stop treatment if you develop pneumonitis (inflammation of the lungs).

Before you take LYNPARZA, tell your healthcare provider about all of your medical conditions including:

  • lung or breathing problems
  • liver problems
  • kidney problems
  • are pregnant or plan to become pregnant. LYNPARZA can harm your unborn baby and may cause loss of pregnancy (miscarriage).
    • If you are able to become pregnant, your healthcare provider may do a pregnancy test before you start treatment with LYNPARZA.
    • Females who are able to become pregnant should use effective birth control (contraception) during treatment with LYNPARZA and for 6 months after receiving the last dose of LYNPARZA.
    • Talk to your healthcare provider about birth control methods that may be right for you.
    • Tell your healthcare provider right away if you become pregnant.
  • are breastfeeding or plan to breastfeed. It is not known if LYNPARZA passes into your breast milk. Do not breastfeed during treatment and for 1 month after receiving the last dose of LYNPARZA. Talk to your healthcare provider about the best way to feed your baby.

Avoid grapefruit, grapefruit juice and Seville oranges during treatment as they may increase the levels of LYNPARZA in your blood.

The most common side effects are anemia, nausea or vomiting, tiredness or weakness, diarrhea, indigestion or heartburn, headache, loss of appetite, changes in how food tastes, changes in kidney function blood tests, sore throat or runny nose, upper respiratory infection, cough, pain in the joints, muscles, and back, rash, and pain or discomfort in the stomach area.

These are not all the possible side effects of LYNPARZA. For more information, ask your healthcare provider or pharmacist.

Call your healthcare provider for medical advice about side effects.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit or call 1-800-FDA-1088 1-800-FDA-1088.

Please see complete Prescribing Information, including Patient Information (Medication Guide).

The information on this Web site should not take the place of talking with your doctor or healthcare professional. If you have any questions about your condition, or if you would like more information about LYNPARZA, talk to your doctor or pharmacist. Only you and your healthcare professional can decide if LYNPARZA is right for you.