Discover LYNPARZA—an oral, non-chemotherapy medication that may give you and your doctor a different option in the treatment of certain types of cancer.
Together with your doctor, you can discuss the possibilities and decide on the unique treatment plan to best help you.
What is the most important information I should know about LYNPARZA?
LYNPARZA may cause serious side effects, including:
Bone marrow problems called Myelodysplastic Syndrome (MDS) or Acute Myeloid Leukemia (AML). Some people who have received previous treatment with chemotherapy, radiotherapy, or certain other medicines for their cancer have developed MDS or AML during treatment with LYNPARZA. MDS or AML may lead to death.
LYNPARZA is a prescription medicine used to treat adults who have:
Your healthcare provider will perform a test to make sure that LYNPARZA is right for you.
It is not known if LYNPARZA is safe and effective in children.
What is the most important information I should know about LYNPARZA?
LYNPARZA may cause serious side effects, including:
Bone marrow problems called Myelodysplastic Syndrome (MDS) or Acute Myeloid Leukemia (AML). Some people who have received previous treatment with chemotherapy, radiotherapy, or certain other medicines for their cancer have developed MDS or AML during treatment with LYNPARZA. MDS or AML may lead to death.
Symptoms of low blood cell counts are common during treatment with LYNPARZA, but can be a sign of serious bone marrow problems, including MDS or AML. Symptoms may include weakness, weight loss, fever, frequent infections, blood in urine or stool, shortness of breath, feeling very tired, bruising or bleeding more easily.
Your healthcare provider will do blood tests to check your blood cell counts:
Lung problems (pneumonitis). LYNPARZA can cause serious lung problems that can lead to death. Tell your healthcare provider if you have any new or worsening symptoms of lung problems, including shortness of breath, fever, cough, or wheezing. Your healthcare provider may do a chest x-ray if you have any of these symptoms.
Blood clots (venous thromboembolism [VTE]). Some people may develop a blood clot in a deep vein, usually in the leg (venous thrombosis) or a clot in the lungs (pulmonary embolism [PE]), which may be severe or lead to death. Tell your healthcare provider right away if you have any symptoms such as pain or swelling in an extremity, shortness of breath, chest pain, breathing that is more rapid than normal (tachypnea), or heart beats faster than normal (tachycardia). Your healthcare provider will monitor you for these symptoms and may prescribe blood thinner medicine.
Liver problems, including Drug-Induced Liver Injury (DILI): People taking LYNPARZA may develop liver problems which may be severe and can lead to death. Your healthcare provider should do blood tests before and during your treatment with LYNPARZA. Tell your healthcare provider right away if you notice discomfort on the right side of your stomach-area (abdominal), dark or “tea-colored” urine, or yellowing of your skin or the whites of your eyes (jaundice).
Your healthcare provider may change your dose, temporarily stop, or permanently stop treatment with LYNPARZA if you get certain side effects.
Before taking LYNPARZA, tell your healthcare provider about all of your medical conditions, including if you:
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Taking LYNPARZA and certain other medicines may affect how LYNPARZA works and may cause side effects.
How should I take LYNPARZA?
What should I avoid while taking LYNPARZA?
Avoid grapefruit, grapefruit juice, Seville oranges, and Seville orange juice during treatment with LYNPARZA since they may increase the level of LYNPARZA in your blood.
LYNPARZA may cause serious side effects (see "What is the most important information I should know about LYNPARZA?").
Nausea or vomiting is common during treatment with LYNPARZA. Tell your healthcare provider if you get nausea or vomiting. Your healthcare provider may prescribe medicines to treat these symptoms.
The most common side effects of LYNPARZA when used alone are:
The most common side effects of LYNPARZA when used in combination with bevacizumab are:
The most common side effects of LYNPARZA when used in combination with abiraterone and prednisone or prednisolone are:
These are not all the possible side effects of LYNPARZA. Call your healthcare provider for medical advice about side effects. You may report side effects related to AstraZeneca products(Opens in new window)
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Please see complete Prescribing Information, including Medication Guide.
For US consumers
The information on this website should not take the place of you talking with your doctor or healthcare professional. If you have any questions about your condition, or if you would like more information about LYNPARZA, talk to your doctor or pharmacist. Only you and your healthcare professional can decide if LYNPARZA is right for you.
LYNPARZA is a registered trademark and AstraZeneca Access 360 is a trademark of the AstraZeneca group of companies.
©2025 AstraZeneca. All rights reserved.
US-105730 Last Updated 12/25
