How to take LYNPARZA alone:

FOR ADULTS WITH mCRPC TUMORS WITH AN HRR MUTATION AFTER PROGRESSION ON ENZALUTAMIDE OR ABIRATERONE

Take LYNPARZA exactly as your doctor tells you. 2 tablets (150 mg each), twice a day, totaling 4 tablets each day by mouth (600 mg daily dose).

2 TABLETS IN THE MORNING (300 mg)

+

2 TABLETS IN THE EVENING (300 mg)

Tablets shown are not actual size.

Take each dose 12 hours apart with or without food. Your doctor will determine how
long you receive LYNPARZA.

If you are receiving gonadotropin-releasing hormone (GnRH) analog therapy, you should continue with this treatment during your treatment with LYNPARZA, unless you have had a surgery to remove both of your testicles (surgical castration) to lower the amount of testosterone in your body.

How to take LYNPARZA in combination with abiraterone and prednisone or prednisolone:

FOR ADULTS WITH mCRPC TUMORS WITH A BRCA MUTATION

Take LYNPARZA exactly as your doctor tells you. 2 tablets (150 mg each), twice a day, totaling 4 tablets each day by mouth (600 mg daily dose).

2 TABLETS IN THE MORNING (300 mg)

+

2 TABLETS IN THE EVENING (300 mg)

Tablets shown are not actual size.

+

Abiraterone
1000 mg taken orally, once daily
+
Prednisone or Prednisolone
5 mg taken orally, twice daily
(Total 10 mg daily)

Tablets shown are not actual size.

Take each dose of LYNPARZA 12 hours apart with or without food. Talk to your doctor about how to take abiraterone and prednisone or prednisolone.

Take each dose of LYNPARZA 12 hours apart with or without food. Talk to your doctor about how to take abiraterone and prednisone or prednisolone.

If you are receiving gonadotropin-releasing hormone (GnRH) analog therapy, you should continue with this treatment during your treatment with LYNPARZA unless you have had a surgery to remove both of your testicles (surgical castration) to lower the amount of testosterone in your body.

Important things to keep in mind when taking LYNPARZA

  • Take LYNPARZA tablets exactly as your healthcare provider tells you
  • Your healthcare provider will decide how long you stay on treatment
  • Do not change your dose or stop taking LYNPARZA unless your healthcare provider tells you to
  • Take LYNPARZA by mouth 2 times a day with or without food
  • Each dose should be taken about 12 hours apart
  • Swallow LYNPARZA tablets whole. Do not chew, crush, dissolve, or divide the tablets
  • If you are taking LYNPARZA for prostate cancer and you are receiving gonadotropin-releasing hormone (GnRH) analog therapy, you should continue with this treatment during your treatment with LYNPARZA unless you have had a surgery to remove both of your testicles (surgical castration) to lower the amount of testosterone in your body
  • If you miss a dose of LYNPARZA, take your next dose at your usual scheduled time. Do not take an extra dose to make up for a missed dose
  • If you take too much LYNPARZA, call your healthcare provider or go to the nearest hospital emergency room right away

What should I avoid while taking LYNPARZA?

Avoid grapefruit, grapefruit juice, Seville oranges, and Seville orange juice during treatment with LYNPARZA since they may increase the level of LYNPARZA in your blood.

Each treatment plan is unique and any questions you might have should be discussed with your doctor.

Existing conditions

Before taking LYNPARZA, tell your healthcare provider about all of your medical conditions, including if you:

  • have lung or breathing problems
  • have kidney problems
  • are pregnant, become pregnant, or plan to become pregnant. LYNPARZA can harm your unborn baby and may cause loss of pregnancy (miscarriage)
  • Males with female partners who are pregnant or able to become pregnant:
    • you should use effective birth control (contraception) during treatment with LYNPARZA and for 3 months after the last dose of LYNPARZA
    • do not donate sperm during treatment with LYNPARZA and for 3 months after your last dose
  • are breastfeeding or plan to breastfeed. It is not known if LYNPARZA passes into your breast milk. Do not breastfeed during treatment with LYNPARZA and for 1 month after receiving the last dose of LYNPARZA. Talk to your healthcare provider about the best way to feed your baby during this time

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Taking LYNPARZA and certain other medicines may affect how LYNPARZA works and may cause side effects.